hello elijah888
Vortex is not necessarily the most up-to-date system, not for EnderalSE
If you absolutely want to use modmanager, then e.g. the current ModOrganizer 2.
Modmanagers like to take control of settings and then ignore launcher settings, at least when working with profiles,
so in your case I would uninstall Vortex and try again (if necessary start the Enderal launcher as administrator)