Hello ranx_0
You probably use Enderal ForgottenStories (32bit)?
Enderal can crash sometimes, it is still based on the old Skyrim engine that can never fully utilize today's hardware.
(about 2 to 4h or more of playtime should be possible without chrash).
Therefore, you should also save frequently, not only with autosave or quicksave, but also with different manual saves.
As for the 3 optimizations, they have different success from PC to PC, but a most users benefit from them.
You can also test the rest of the launcher settings to see what works best for you.
For example, the number of your CPU core, the usable RAM, various visibility.
Alternatively, try lowering shadow and grass visibility (even though you have good hardware).
Are you using any mod's? if yes, deactivate or better uninstall them and repair your Enderal-installation with Steam and then test it again.
You can of course wait for the 64bit version (Enderal: Forgotten Stories - Special Edition), which is being tested a lot (for that you need SkyrimSE on Steam),
but your previous savegames are not compatible.