Here's an odd one. Every so often something happens movement-wise where sprinting and running become disabled for the save. I can't put my finger on exactly what causes it, but it's definitely the save and not a corruption to prefs setting, because I can back out to an earlier save and it goes away. Quitting to desktop and reloading the save doesn't fix it either. Neither does passing through a map transition. In this instance it happened at some point during the fight that's about to take place, because I can sprint and jump in the one but not the other.
Hasn't been a game-breaker so far, but it's weird.