hi, welcome to the forum
there are some thing you can try:
- disable ENBoost and/or OneTweak (or enable them)
- make sure that no additional mods are installed or activated.
-Make sure your anti-virus-program, windows defender or firewall are not blocking the Enderal Launcher.exe, tes5.exe and skse_loader.exe. Furthermore make sure they all run with admin permissions.
- check the integrity of game files
- try restarting Steam and/or your PC.
- change settings in the Enderal Launcher, make sure the CPU and RAM usage are maxed out in the optimization tab.
- try redownloading the game
hope something of that list already helps
