Hi, welcome to the forum.
Have you tried removing your Skyrim.ini and SkyrimPrefs.ini from C:\User\Documents\mygames\Skyrim\ and then start the launcher and game afterwards. Both inis will be recreated when the game starts running.
If it still does not start, please upload your Launcher.log which you can find in your Skyrim game directory: ...\Skyrim\EnderalLauncher\system\log\
A screenshot of the contents in ...\Skyrim\Data\ would be also helpful.