I'm also having a problem here, and kind of at a loss as to what to do. When the screen turns to black for the second time, after finishing "In The Lion's Den" and the loading screen appears (with no image in the middle or text below, just an empty frame), in a few seconds the game crashes. I tryed messing around with the graphical settings (like lowering them), memory and CPU usage settings (I have none of the experimental settings activated here), trying it with and without OneTweak. Also did it with and without ENB activated (I use Vivid Ender ENB).
I have a couple mods installed, but mainly texture and/or mesh replacers, and some animation mods. Aside from that, minor gameplay/UI enhancements that as far as I see should have no effect on this. Lastly, I have DynDOLOD. Could any of these cause this? I could send a complete list of mods if needed.
Thanks in advance for any help.