if that only (mostly?) happens after a reboot, you could take a look into Windows' event log
(I can only give you german translations - actual words can be different):
(right after the next crash)
- search via taskbar for "event viewer"
- in that screen, open "custom views" and then something like "administrative events"
- is there anything of
particular interest in that list on the right?
something like skse / Enderal launcher /... stopped working?
(there are probably a lot of errors; most of them can be safely ignored)
did you try to redownload the mainfile?
maybe it's corrupted for some reason
torrent would be the safest.